Many reports reported that association of psoriasis with metabolic syndromes , and its components, such as obesity, diabetes, and hypertension. These reports suggest that the risk of developing DM is slightly increased in patients with psoriasis as compared with patients without psoriasis. The risk estimates were highest for patients with psoriasis with a longer psoriasis history who regularly received systemic treatment, possibly reflecting greater disease severity. In other study it's reported that the risk of diabetes was independent of BMI ( body mass index ) . Inflammation could be a biologically plausible mechanism underlying this association; insulin resistance has previously been attributed to inflammation, and elevated C-reactive protein levels are predictive of diabetes.
The increased prevalence of diabetes in patients with psoriasis was independent of traditional diabetes risk factors such as obesity and dyslipidemia in a large, population-based cross-sectional study in the UK. A small cross-sectional study demonstrated weak, but statistically significant associations between psoriasis severity and markers of insulin resistance .
Th-1 inflammatory cytokines such as TNF-α are elevated in the skin and blood of patients with psoriasis and are critical to recruiting T cells to the skin and joints, promoting angiogenesis, and epidermal hyperproliferation. Similarly, TNF-α is secreted in adipose tissue and is an important feature of the chronic low-level inflammation seen in obesity. Insulin resistance, which is common to psoriasis and the metabolic syndrome, may be mediated in part through inflammatory cytokines such as TNF. For example, TNF may lead to insulin resistance through a variety of pathways such as impairing insulin signaling by inhibiting the tyrosine kinase activity of the insulin receptor; by activating peroxisome proliferator-activated receptor (PPAR) δ which promotes epidermal proliferation and modulates adipogenesis and glucose metabolism; and by suppressing adiponectin secretion from adipocytes, which is an important anti-inflammatory molecule that also functions in regulating insulin sensitivity. Furthermore, chronic inflammation in psoriasis leads to increased insulin-like growth factor-II (IGF-II) in the skin and blood of psoriasis patients. IGF-II promotes epidermal proliferation and is also implicated in promoting atherosclerosis, in modulating body fat mass and lipid metabolism in mice, and is linked to diabetes and hyperlipidemia in animal and human models 3.
The thiazolidinedione drugs including troglitazone (now discontinued), rosiglitazone and pioglitazone, used as insulin sensitizing drugs in the treatment of diabetes can improve psoriasis through interaction with these receptors .
Also it's reported that SSR-162369 DPPIV inhibitor drug developed by Sanofi-Aventis ( This compound is probably a structural analog of vildagliptin ) was found to be useful for the treatment of skin disease (e.g., acne and psoriasis) .
Alternatively, therapy for psoriasis may promote development of diabetes, especially if patients were treated with systemic steroids. Nonetheless, systemic steroids are not the standard of care for psoriasis in the United States and are typically avoided in patients with psoriasis owing to the potential for disease worsening .The topical steroids that are often used in the treatment of psoriasis may be systemically absorbed if they are used on large body surface areas for extended periods. The long-term use of topical steroids on large body surface areas could explain the observed increase in risk for diabetes, although adherence with long-term topical steroids use is generally low .
Also it's reported that methotrexate , cyclosporine and calcitonin can induce diabetes .
So people who are diabetic and suffer from diabetes should be aware with the drugs used .
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I f you want to be free from your psoriasis through special guide and people who use this and they treated from psoriasis . Even Plaque , Gutate , Scalp , Nail , pustular and inverse psoriasis
and Save your money
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