Laser Treatment Promising in Psoriasis, June 10, 2002 -- The 308-nm excimer laser may prove to be the treatment of choice for vitiligo and psoriasis, based on results of two pilot studies reported in the May issue of the Journal of the American Academy of Dermatology. In a separate study, the same laser offered psoriasis patients more rapid response with less long-term risk to healthy skin than is typically seen with standard therapy using psoralen plus ultraviolet A. With 308-nm UV-B radiation generated by an excimer laser, it is possible to clear psoriasis with as little as 1 treatment with moderately long remission. In contrast to traditional phototherapy techniques, this handheld excimer laser UV-B therapy is selectively directed toward lesional skin, thus sparing the surrounding normal skin from unnecessary radiation exposure. Treatment of other inflammatory diseases and limited psoriasis seems reasonable to pursue with this modality. A recent study showed that a laser beam of ultraviolet light can clear psoriasis patches in a single treatment with a fairly long remission, but blistering was common
Also by experiment the use of 1% ALA-PDT ( Topical aminolaevulinic acid-based photodynamic therapy ) in combination withlight doses ranging from 5 to 20 J cm ) was investigated for chronic localized plaque type psoriasis. An unsatisfactory clinical response, a slow pace of improvement and the frequent occurrence of pain during and after irradiation renders topical ALA-based PDT( which lead to formation protoporphyrin IX (PpIX) an inadequate treatment option for psoriasis. Alternative photodynamic regimens such as systemic ALA in combination with blue light or systemically administered verteporfin in combination with red light might provide better therapeutic results. However, the effectiveness of such alternative approaches has yet to be substantiated by controlled studies in larger series of patients
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